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Scientific Data: In the OASIS 4 trial, 74% of participants experienced at least one gastrointestinal side effect

GLP-1 functions as an immune modulator because it controls macrophage polarization and T-cell functions [12,13]

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Although research specifically on Retatrutide is limited, data from similar GLP-1 medications suggests nausea may be slightly worse during the luteal phase (days 15-28) when progesterone peaks and GI motility naturally slows

The nausea results from GLP-1 receptor activation in both the gut (slowing gastric emptying) and the brainstem (activating the area postrema)