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In the absence of GPX4, lipid peroxidation via 12/15-lipoxygenase leads to activation of the apoptosis-inducing factor (AIF) to induce cell death

Behav Brain Res 436:114083

Although the acetyl group of aspirin did get its fair share of attention after the discovery of its mechanism of action through the inhibition of the COX enzymes in the 1970s, it has since been largely ignored

The blend lets researchers examine all three pathways in one system, which is the underlying rationale for the 50/10/10 composition and the co-lyophilization approach