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Intriguingly, it was found that normalized debutyrylation efficiencies at H3K36 and K37 were 3.335.44 and 2.583.59, respectively, suggesting that the butyryl groups at H3K36 and K37 are highly efficiently removed by Sirt7 compared to the butyryl group at H3K18

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A SIRT2-selective inhibitor promotes c-Myc oncoprotein degradation and exhibits broad anticancer activity

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