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Growth hormone inhibiting hormone (GHIH) initiates a negative feedback mechanism to stop the secretion of any more growth hormone (GH) by the somatotroph cells so that hormonal levels dont overshoot

People with Type 2 diabetes prescribed semaglutide (Ozempic, Wegovy) had a significantly lower risk of an opioid OD than patients taking any of eight other diabetic medications, researchers found

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It is careful to add that this remains speculative without clinical documentation of a direct pathway, so the mechanism is a hypothesis rather than something the evidence supports