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Patent protections for semaglutide (Ozempic/Wegovy) expire in 2026 in Canada, India, Brazil and China, opening the door for lower-cost biosimilar generic versions

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The biosynthesis pathway is similar in plants, yeast, and bacteria [28], and involves a series of enzyme-mediated reactions [29] starting from guanosine 5-phosphate (GTP) and two molecules of ribulose 5-phosphate (Ribu5P) (Figure 3) [30]

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Tirzepatide is a novel glucose-lowering medication approved by the FDA in May 2022 for the treatment of type 2 diabetes mellitus in adults