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Mechanistically, cholesterol induced a hepatic metabolic reprogramming characterized by enhanced oxidative phosphorylation and antioxidant defenses, coupled with suppression of endoplasmic reticulum (ER) proteostasis

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Conclusion This review distinctively highlighted the in vitro, in vivo, and clinical studies conducted on the neuroprotective potential of natural compounds in Parkinsons disease (PD), discussing the various models of PD used, specified concentrations or doses of natural compounds, and the mechanism of their actions

Vet Res 56(1):46 Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS et al (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death

By fighting oxidative stress in the brain, glutathione can also contribute to improved mental clarity and focus