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J Biol Chem (2009) 284(25):1697989.10.1074/jbc.M808153200 53 SinghSOkamuraTAli-OsmanF

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Melatonin Dosage for Adults Melatonin for Trouble Falling Asleep 0.3 to 5 mg of melatonin, not to exceed 9 months may help people who have trouble falling asleep 6 Melatonin for Disrupted Sleep-Wake Cycle 2 to 12 mg taken at bedtime for up to 4 weeks, may help get your natural rhythm back on track 6 Melatonin for Extended Difficulty Sleeping most research studies have used 2 to 3 mg of controlled-release melatonin for up to 29 weeks

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