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What the Clinical Data Says About Extended Treatment The backbone of everything we know about extended Retatrutide use comes from the Phase 2 SURMOUNT-1 trial, which tracked 338 participants across multiple dose groups for a full 48 weeks

Volkow, N.A

A key limitation is the imbalance in datasets, which often contain numerous biological features but relatively few patients, increasing the risk of overfitting and reducing model generalizability [55]

Let us examine what the research says about each one, what doses appear in the formula versus what studies used, and where the gaps might be