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Upregulated gene sets included those associated with GPCR signaling, neuropeptide receptor interactions and ligand binding, cilia formation, metabolic processes, and endocrine function Supplemental Figure 5B)

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Significant functional decline warrants immediate medical attentionthis includes new difficulty climbing stairs, rising from a chair without assistance, carrying groceries, or performing routine daily activities that were previously manageable

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Notably, recent studies demonstrate that resveratrols pro-apoptotic effects are dose- and time-dependent, with IC50 values of 51.18 M and 57.4 M observed in breast (MCF-7) and hepatocellular carcinoma (HepG2) cells after 24-h treatment [15]