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Alterations of antioxidant enzyme expression in response to hydrogen peroxide

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In response to an increase in the cytosolic Ca 2+ concentration, the Gardos channel opens, resulting in the efflux of K + with subsequent hyperpolarization driving Cl - exit (through Cl - channels)

Upstream cysteine supply block, NADPH control, glutathione reductase activity repression, GSH efflux pumps stimulation, and so on have proven to be feasible approaches to ablate tumors (Xiong et al., 2021)