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A GLP-1 blocker acts by inhibiting the GLP-1 receptor, which modulates the downstream inflammatory pathways linked to: cytokine production immune system activation oxidative stress inflammatory signaling in tissues such as the liver, fat cells, and gut In low doses, blocking GLP-1 receptors appears to influence the immune system without significantly interfering with glucose control which is why this approach is being studied specifically for inflammation rather than metabolic disease
In recent computational studies, AG1 was used as a scaffold for a structure-based pharmacophore screen where five compounds were identified as potential activators of G6PD [102]