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It works by mimicking the effect of the body's own intestinal hormone GLP-1 (glucagon-like peptide-1), which affects appetite regulation, satiety, and glucose metabolism
These patients often require higher doses (350-450mcg) achieving similar results as metabolically healthy patients at lower doses
These medications naturally reduce appetite, which often leads to reduced food intake without effort
42 Likewise, a systematic review of 41 studies involving overweight or obese participants showed a significant reduction in total-hip BMD (0.0100.015 g/cm 2 ) after weight-loss interventions lasting six months or longer, whereas lumbar-spine BMD remained stable
12 and Supplementary Movie 7)
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