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The most common adverse events included nausea, affecting 38.1% to 43.2% of treated patients compared to 10.7% with placebo, diarrhea in 33.1% to 34.7% versus 13.4% with placebo, and constipation in 21.8% to 25% compared to 8.7% with placebo

Some patients experience mild fatigue during the first two weeks

Originally developed as a treatment for diabetes, Semaglutide was later discovered to be highly effective for weight management, which led to its approval for obesity treatment under the brand name Wegovy

Symptoms are usually mild to moderate and may include loose or watery stools, urgency, or more frequent bowel movements

6 Cleveland Clinic, GLP-1 Agonists, July 3, 2023