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The human 2 ketoglutarate dehydrogenase complex while extensively studied has not yet been reconstructed in vitro and reliance on other mammal models persists [5, 48](Fig 4)

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Healing cascade activation may begin quickly, but measurable structural repair in intestinal lining models takes longer

It is a specific cofactor for a large family of enzymes known as the Fe- and 2-oxoglutarate-dependent dioxygenases that catalyse the addition of a hydroxyl group to various substrates (Wei et al