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The connection is indirect but biologically meaningful

Efficacy and safety of once-weekly semaglutide 20 Mg versus 10 Mg in patients with type 2 diabetes (sustain forte): A double-blind, randomised, phase 3B trial

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Chronic alcohol consumption does the same through a different pathway, damaging the gut lining and sending inflammatory signals through the vagus nerve

Conclusion Dietary modification personalized to individual preferences and treatment goals (e.g., caloric deficits of 500 kcal/day), combined with structured physical activity (e.g., 150 minutes of moderate-to-vigorous exercise per week), produces additive benefits beyond GLP-1 therapy alone, enhancing weight loss, improving body composition, and reducing visceral fat and inflammation