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Hyperglycemia can inhibit autophagy activity in proximal tubular cells by activating mTOR Complex 1 (mTORC1), a nutrient status sensor involved in cell growth, development and proliferation (105)

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Like GLP-1, OXM has demonstrated incretin activity (incretins stimulate insulin release in response to food intake) and this activity is abolished in the GLP-1R knock-out mouse