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La coactivacin de ambas rutas produce un efecto sinrgico: el anlogo de GHRH amplifica la amplitud del pulso mientras el secretagogo de ghrelina suprime parcialmente la somatostatina y aade un estmulo independiente, de modo que la liberacin conjunta de GH observada en modelos supera la suma de cada componente por separado

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It adds that people with a family history of diabetes or with metabolic syndrome often see stronger appetite and glucose benefits, while noting that the clinical evidence on individual response magnitude is still accumulating