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Am J Physiol Endocrinol Metab (2012) 302:E7786

It is well known that proteasomes (complex intracellular proteases) are able to mildly degrade oxidized proteins (Dunlop et al

Monney M, Jornayvaz FR, Gariani K

Whether knocking out the GPX4 gene or inhibiting its activity, it can eventually lead to a redox homeostasis imbalance that can have a fatal effect on normal or tumor cells