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There were no differences in amino acids, vitamins, glucose or palmitic acid in the stool between Cse +/ and Cse / mice, indicating no defects in nutrient absorption (Extended Data Fig

Too much variation in either direction creates problems: Doses too far apart (9+ days): blood levels drop below the therapeutic threshold, reducing appetite suppression and glucose control Doses too close together (5 days or less): blood levels climb higher than intended, increasing nausea, vomiting, and other GI side effects The question "can I take it a day early" is really asking: how much timing flexibility exists before I create one of those two problems

However, persistent deviations from the recommended dosing conditions will lead to gradual changes in exposure over time

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Studies on mice have shown that activation of androgen receptors by dihydrotestosterone in the brains of the tested animals led to the development of IR, whereas rodents deprived of these receptors did not develop this type of disorder