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Such parallels highlight the evolutionary conservation of redox-buffering strategies that maintain cellular homeostasis under stress

With respect to insulin receptor signaling proteins, insulin receptor substrate-1 (IRS-1), phosphatidylinositol-3-kinase (PI3K), protein kinase B/AK strain transforming (AKT/PKB), PIP 3 -dependent kinase 1 (PDPK1), and glycogen synthase kinase 3 (GSK3) are all known to be O -GlcNAcylated

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