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doi: 10.1177/1759720x21989868 8 MunSLeeJParkMShinJLimMKKangHG

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The salt bridge between R283 6.55 and E124 3.33 exists in both antagonist-bound and active ghrelin receptor structure, however, in contrast to antagonist compound 21, ghrelin or GHRP-6 pushes the side-chain of R283 6.55 to swing away from the receptor helical core, which induces rotation of TM6 that initiates the cascade of conformational changes in receptor activation (Fig

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Emotional and Psychological Support: Weight loss journeys can be emotionally challenging