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But basically, lets start with, are they safe in general, and are they safe for the long term

223,224 The most widespread modification methods include backbone, ribose, and nucleobase modifications

And like everything else, you know, when you start looking at digging, research and try to figure out what's out there, what can, what, what can move the needle, right

10.1111/j.1470-8744.1990.tb00136.x 68 TonettiM.ZocchiE.GuidaL.PolvaniC.BenattiU.BiassoniP.et al (1992)