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Activated mast cells release pro-inflammatory cytokines such as IL-1, IL-6 and TNF- as well as bronchoconstrictor mediators such as histamine, prostaglandin-D2 and leukotriene-C4

Reflecting a growing acceptance of obesity as a legitimate medical condition, at least in the United State, a 2024 employer health benefits survey found that 61% of respondents support expanding Medicare (federal health insurance program primarily for individuals aged 65 and older) coverage beyond treatment for T2DM to include GLP-1 therapies for weight management in overweight individuals (Kaiser Family, F, 2024)

Specifically, PP increased 3-6% while MP improved 2-5%

Results in rodent models have shown that exposure to LAN accelerates mammary tumor development, increases estrogenic activity, and reduces circulating melatonin levels 159

USA 113 , E2047E2056 (2016)