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Loss of macrophage mTORC2 drives atherosclerosis via FoxO1 and IL-1beta signaling

It also modulates the FAK-paxillin pathway to drive fibroblast spreading and migration

To do this, they created a sort of evil FOXO4 twin called a FOXO4-DRI peptide it looked and acted like FOXO4 from a chemical perspective (in fact, p53 liked to bind with FOXO4-DRI even more than regular FOXO4, which is important because of some complicated chemistry), but FOXO4-DRI didnt only live in the nucleus it could exist anywhere in the cell

Learn More Metabolism Supports metabolic health and helps stabilize blood sugar