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246 In contrast, by the inhibitory effect on FDPS, bisphosphonates also inhibit the function of Rho GTPases by disrupting prenylation-dependent signaling, 244 thus leading to the apoptosis of osteoclasts due to the impaired mobility and adhesion of these cells

From an eating disorder perspective, the root driver of food noise is restrictive, disordered eating, which has many psychological and social underpinnings that also need to be addressed

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This configuration supports receptor-level interaction within adipocytes while minimizing affinity for the growth hormone receptor, distinguishing it from full-length GH and preventing downstream IGF-1 pathway activation