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R.AhsanN.KastoffG.HyamsJ

3 COMT inhibitors, such as entacapone, opicapone, and tolcapone, and MAO-B inhibitors, such as selegiline, rasagiline, and safinamide, work by enhancing levodopas duration of action with inhibition of their respective enzymes

[DOI] [PMC free article] [PubMed] [Google Scholar] 283.Degirolamo C., Rainaldi S., Bovenga F., Murzilli S., Moschetta A

The identified root causesunclear GDP expectations, lack of SOPs requiring retention and annotation of defective printouts, employee misinterpretation, and weak controls over raw dataare symptomatic of a quality system maturity failure, not isolated human error

It's a physiological tug-of-war where your goals are the rope, and youre pulling against yourself