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Within hepatocytes, inosine also activates PKA which in turn activates CREB signaling

10.3389/fcvm.2022.906753 26

It promotes the activity of lymphocytes and is involved in the maturation of DCs, Th cells and cytotoxic T cells

Chronic pain often involves nervous system sensitization, metabolic dysfunction, nutrient depletion, or low-grade inflammation that may not appear on standard imaging or routine laboratory tests