Sodium deoxycholate (NaDOC) is another GSH depleting drug that produces OS, as indicated by ROS generation and mitochondrial swelling leading to inhibition of intestinal Ca 2+ absorption[53]
In contrast, although there is no gross ventricular deformity in SANS, there are reports of increasing ventricular diameter [23,24,25, 28, 30, 34, 35, 112, 113]
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Consistent with these findings, H&E staining of liver sections revealed significant lipid accumulation in SKO mice that was considerably reduced by liraglutide treatment in female SKO mice ( Figure 3C ) but this was not evident in liraglutide-treated male SKO mice ( Figure 3D )
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