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Through the reduction of Fe(III) shown in Reaction 1, O destroys the Fe-S clusters of proteins, and the reduced iron undergoes additional redox reactions that cause more injuries, as described below (44)

For E1, the higher abundance of hydroxylated E1 also resulted in an increased abundance of 2- and 4-MeOE1, although these increases did not seem to be proportional to those observed for the hydroxylated metabolites

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