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Total Insulin and IGF-I Resistance in Pancreatic Beta Cells Causes Overt Diabetes

Two reviewers independently conducted the quality assessments, and any discrepancies were resolved through discussion or consultation with a third reviewer (A.N

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To further investigate the transcriptional changes in functionally coordinated genes, Gene Set Enrichment Analysis (GSEA) 33 was performed using the Kyoto Encyclopedia of Genes and Genomes (KEGG) functional gene sets available in MSigDB ( The top 10 downregulated and 10 upregulated KEGG gene sets in GLA-mutant Fabry kidney organoids compared with WT kidney organoids are shown in Supplementary Table 2