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Because we just dont know yet exactly what the long-term outcomes are for people who become pregnant while taking these medications. One early study suggested that using GLP-1 agonists during the first trimester didnt harm fetal development
This is especially problematic when GLP-1s are already reducing gastric motility
Clinical studies indicate that in individuals with T2DM and obesity, oral semaglutide at a dose of 14 mg can improve HbA1c levels by up to 1.4% and reduce body weight by approximately 4.4 kg.95 A 68-week phase III trial assessed the efficacy and safety of daily oral semaglutide 50 mg combined with moderate-intensity lifestyle interventions versus placebo in a cohort of obese individuals without T2DM
Why Proper Storage Matters for Compounded Medications
The 12mg weekly arm produced a 24.2% mean body weight reduction over 48 weeks, with 26% of participants achieving at least 30% total body weight loss a threshold previously unattained by any pharmacological intervention in a clinical trial setting
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