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Oxidized PAC-quinone imine metabolites have also been shown to form GSH-conjugates which inhibit glutathione reductase (GR): the decreased activity of GR hampers the detoxification and antioxidant capacity of the GSH-GSSG cycle, further aggravating the pro-oxidative status in the cell (Ndlov et al., 2014)

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Some patients report temporary dizziness, nausea, or headache after an injectionthese may relate to copper or peptide effects and typically resolve within hours

Plasma concentrations in humans are reported in the range 220 M for GSH [1, 13, 14], and 0.140.34 M for GSSG [13, 14, 42]

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