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However, Heinz bodies are a very transient finding because they tend to be promptly pinched off by the spleen (thus giving rise to bite cells), and the red blood cells that contain them are very rapidly removed from the circulation

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Indeed, GIP administration reduces cell apoptosis and enhances cell mass in animal models [32]

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The increased oxidation of the cell biochemical constituents is associated with ultra structural changes in mitochondrial morphology with mitochondrial swelling and increased matrix volume (Boveris et al., 2008)