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Importantly, tamoxifen activity against viral infections, such as Ebola or SARS-CoV-2 infections, has been associated with inhibition of sphingolipid metabolism and alterations in endosomal calcium and cholesterol traffic (Fan et al., 2017

However, very high intakes of PEITC or BITC (25 to 250 times higher than average human dietary isothiocyanate intakes) have been found to promote bladder cancer in rats when given after cancer initiation by a chemical carcinogen (70)

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