glp-1 shortage update Taking Stock: What Ro's Supply Tracker Reveals about the Drug Shortages GLP-1 Pipeline Update: August 2025

One study (87) provides evidence that pro-GLP-1 prevented apoptosis induced by oxygen-glucose deprivation (OGD) in cultured cortical neurons, and exerted neuroprotective effects through the cAMP/PKA and PI3K/Akt signaling pathways but not the ERK pathway in mice against cerebral ischemia

The Roundhill GLP-1 & Weight Loss ETF (OZEM) seeks to gain exposure to companies pioneering the development of cutting-edge weight loss treatments

Semaglutide may contribute to weight loss by affecting appetite regulation

Adding urgency to this conversation, BMJ meta-analysis found that GLP-1 treatment discontinuation typically occurs within the first year, and that weight regain after stopping can be more rapid than after dietary interventions alone

Leptin in relation to prostate cancer and benign prostatic hyperplasia