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Both are unapproved research chemicals the 2026 compounding landscape remains in flux but that is not the same as FDA approval

11 Lack of supply There is a shortage of both semaglutide and tirzepatide due to their unprecedented demand, with both now listed in the FDA Drug Shortages database, allowing for compounded versions to be made (although that does not make such versions FDA-approved)

Additionally, the study population was relatively small, and the number of included studies was limited