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Large-scale, population-based cohort studies have demonstrated an association between T2D and an increased risk of developing PD, with hazard ratios ranging from 1.2 to 1.5, depending on the study design and population [6, 25,26,27,28]

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155 Individuals with diabetes and hyperglycemia had significantly higher levels of inflammatory mediators, such as IL-6, C-reactive protein, serum ferritin, and D-dimer, suggesting increased vulnerability to inflammation storms and higher mortality