In vitro studies indicate that hepatic resident macrophages detect elevated free fatty acids and respond by increasing TNF- secretion that, in turn, promotes the progression of steatosis in hepatocytes ( Metabolic burden in hepatocytes activates multiple cell death pathways, including apoptosis, necroptosis, pyroptosis, and ferroptosis, which can further amplify the inflammatory and fibrogenic response ( Figure 1B )
Think of it as helping to tune up your body's engine to burn fuel more cleanly
Tan, uneven patches, and surface discolouration begin to resolve
Excess Pigmentation In many cases, dark circles are caused by an overproduction of melanin under the eyes
This underscores ferroptosis as a key pathological feature and a promising therapeutic target for CKD treatment