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If symptoms persist beyond several weeks, disrupt sleep, or include pain or urgency, evaluation is recommended

Additionally, conflicting findings suggest that prolonged metformin treatment may exacerbate AD pathology in genetically susceptible models, increasing -amyloid accumulation, tau phosphorylation, and synaptic dysfunction 92

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Updated July 2026 The Ozempic and GLP-1 lawsuits involve claims that manufacturers of medications such as Ozempic, Wegovy, Mounjaro, Rybelsus, Trulicity, Zepbound, and Saxenda failed to adequately warn patients and doctors about potential risks of developing gastroparesis (stomach paralysis), ileus (bowel obstruction), deep vein thrombosis (DVT), intraoperative pulmonary aspiration and NAION eye injury (sudden vision loss)