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Gastrointestinal issues top the list of concerns, but gallbladder symptoms, thyroid cancer risks, and mental health questions are all part of the evolving safety profile

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Microglial activation mediates chronic mild stress-induced depressive- and anxiety-like behavior in adult rats

In a July 2024 retrospective, electronic health record (EHR) study in 41,222 adults with overweight or obesity treated for type 2 diabetes, 81.8% of people receiving tirzepatide (Mounjaro) lost at least 5% of their weight within one year compared to 66.5% of those using semaglutide (Ozempic), a significant difference (which means it did not just happen by chance)

They can be particularly effective for individuals who have struggled to lose weight through diet and exercise alone