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Microbes are vital contributors to the host metabolism, considering that numerous important components, such as vitamin K, indoles, gamma amino butyric acid, folate, and short-chained fatty acids (SCFAs), are produced by microbiota (Brown and Hazen, 2018)

Moreover, strong evidence links poor nutrition and obesity to the rising prevalence of chronic inflammatory and immune-mediated disorders, including autoimmune diseases [10]

This modulation can lead to decreased inflammation in tissues

Apremilast disrupts the feedback loop sustaining psoriatic plaques by inhibiting dendritic cell activation and Th17 differentiation (Schon & Erpenbeck 2018

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