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adding a second dose in the early afternoon extends cognitive benefits through the workday

Long term prescription of medications such as the following are likely to increase the cause of, or exacerbate the risk of B12 deficiency - the proton pump inhibitors (esomeprazole, lansoprazole, omeprazole, pantoprazole, rabeprazole), famotidine, ranitidine, metformin, glibenclamide, gliclazide, glimepiride, glipizide, sodium valproate, gabapentin, doxycycline, some oral contraceptives

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Depending on the individuals body type and health, they may require shots daily, weekly, or monthly

Di Somma C, Scarano E, Barrea L, Zhukouskaya VV, Savastano S, Mele C, et al