AL Lpez-Lpez, HB Jaime, MDC Escobar Villanueva, MB Padilla, GV Palacios, FJA Chronic unpredictable mild stress generates oxidative stress and systemic inflammation in rats
That being said, different mechanisms may offer different side effect profiles, and its possible that future multi-agonists could yield improved tolerability profiles
Several factors may contribute to dizziness in patients taking GLP-1 medications: Hypoglycaemia (low blood glucose) particularly when GLP-1 agonists are used alongside other glucose-lowering medications such as sulphonylureas or insulin Dehydration resulting from reduced fluid intake due to decreased appetite or from gastrointestinal side effects such as nausea, vomiting, or diarrhoea Orthostatic hypotension a drop in blood pressure upon standing, which may occur due to volume depletion or rapid weight loss Reduced caloric intake significant appetite suppression may lead to inadequate nutrition, potentially causing weakness and dizziness The frequency and severity of dizziness vary between individuals and specific GLP-1 products
Information is obtained from the manufacturer's website
Notably, Simlandi is the first high-concentration, citrate-free and interchangeable Humira biosimilar to be approved in the U.S., according to Alvotechs announcement