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Food and Drug Administration for the treatment of either known or suspected cyanide poisoning.[i] Cyanide (CN) can be released by virtually any material containing carbon and nitrogen when burned under high temperature and low oxygen conditions.[ii],[iii] There is high potential for CN toxicity at many fire scenes due to the increased use of synthetic materials that produce CN during combustion in closed-space fires.2,3 Moderate to high concentrations of cyanide can cause severe injury and death within minutes.[iv] Therefore Cyanide poisoning is a life-threatening situation that requires immediate medical attention

Specifically, lipopolysaccharide (LPS)-induced thrombocytopenia is dependent on platelet expression of TLR4 (Refs 51,53), and recent evidence suggests that platelets can actively bind circulating bacteria and their products and present these to neutrophils and cells of the reticuloendothelial system 53,54,55,56,57

Cheng, G

This "fragment + stabiliser" method is a Russian methodological signature, widely used subsequently by the Khavinson, Myasoedov groups, and more recently by Chinese and Indian teams