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In the context of wet age-related macular degeneration (AMD), geniposide (GEN), a GLP-1RA, is found to downregulate HB-EGF (heparin-binding epidermal growth factor) secretion from retinal pigment epithelium (RPE) cells under hypoxic conditions through the miR-145-5p/NF-B signaling axis

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However, several strategies that target pathophysiological processes such as an oversupply of fatty acids to the liver, cell injury and inflammation are currently under investigation

Maziade 2015)