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Kosiborod, M.D., from Saint Luke's Mid America Heart Institute in Kansas City, Missouri, and colleagues randomly assigned 616 patients who had heart failure with preserved ejection fraction, a body mass index of 30 kg/m 2 or more, and type 2 diabetes to receive semaglutide or placebo once a week for 52 weeks

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In addition, PKA inhibition attenuated the effects of metformin on PA-induced endothelial dysfunction, suggesting that PKA may be involved in the protective effects of metformin on endothelial cells

doi: 10.1172/JCI103943