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Plain Language Summary Dark spots and uneven skin tone, known as hyperpigmentation, are a common skin concern affecting many people worldwide and can cause significant distress

[26] In addition, glutamate plays important roles in the regulation of growth cones and synaptogenesis during brain development as originally described by Mark Mattson

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Klugman and colleagues have shown that in the United States PLWH were diagnosed with non-small cell lung cancer at a younger age compared to seronegative participants, with lower median survival time especially among those with a low CD4/CD8 ratio and high viral loads (146)

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