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When in doubt, replace the product

Neuron 17 : 945956

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Phospholipase C's role in signal transduction is its cleavage of phosphatidylinositol 4,5-bisphosphate (PIP 2 ) into diacyl glycerol (DAG) and inositol 1,4,5-trisphosphate (IP 3 ), which serve as second messengers

In briefing documents for the meeting, the FDAs experts said there is a lack of evidence on effectiveness and safety to justify letting pharmacies make the peptides that the panel will review