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Concurrently, efforts are underway to identify more reliable biomarkers, such as markers of oxidative stress, inflammation and neuronal damage, to enable earlier diagnosis and better monitoring of DPN progression and therapy response

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DPP-4 inhibitors have the advantage of decreasing glucagon by augmenting levels of incretin hormones, particularly driving insulin secretion in hyperglycemia to avoid glucagon overproduction

Lab work: Some providers require periodic blood work to monitor metabolic markers