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The function of histamine in a specific part of the body depends on the receptor it binds to

This NAD+ elevation activates sirtuins, particularly SIRT1 in adipocytes and hepatocytes, which deacetylates and activates numerous metabolic regulatory proteins including PGC-1, a master regulator of mitochondrial biogenesis, oxidative metabolism, and thermogenesis

In research it is valued as one of the most selective growth hormone secretagogues: it prompts GH release while having little effect on other hormones such as cortisol or prolactin, giving researchers a clean tool for studying this pathway

Mitochondria are mainly found in the dendritic shafts but can also reach the spines [59]

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